Compared to people who are of normal weight and metabolically healthy, subjects who are of normal weight but metabolically unhealthy (~20 percent of normal weight adults) have a more than three-fold higher risk of mortality and/or cardiovascular events. This risk is also higher than that of metabolically healthy obese subjects. Norbert Stefan, Fritz Schick and Hans-Ulrich Häring have now addressed characteristics determining metabolic health in lean, overweight and obese people, showed that a reduced accumulation of fat in the lower body puts lean people at risk and highlighted implications of their findings for personalized prevention and treatment of cardiometabolic diseases.
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